| janiceru2 | Дата: Четверг, 14.05.2015, 19:21 | Сообщение # 1 |
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| tcsindustryz | Дата: Воскресенье, 26.06.2016, 06:52 | Сообщение # 2 |
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Группа: Гости
| Docetaxel (as generic or underneath the trade eminence Taxotere) is a clinically well-known anti-mitotic chemotherapy medication (medication which interferes with stall allotment). It is worn mainly for the treatment of heart, ovarian, prostate, and non-small chamber lung cancer.<> - <> - <> - Docetaxel has an FDA approved call for representing treatment of patients who partake of locally advanced, or metastatic heart of hearts or non small-cell lung cancer who procure undergone anthracycline-based chemotherapy and failed to stop cancer advance or relapsed<> - and a European imprimatur payment licence in hormone-refractory prostate cancer.<> -
According to a 2005 article in the annual Drugs, docetaxel administered as a one-hour infusion every three weeks generally settled a ten rotate track, docetaxel is considered as or more effective than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.<> - No matter what the effectiveness of docetaxel versus paclitaxel and other taxanes is undisturbed controversial. Individual more current articles father build "no confirmation that regimens containing docetaxel cry quits greater benefits than those including paclitaxel."<> - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week administration register old to be and is stationary considered effective but new studies are indicating a weekly plan might be better. A 2010 article in Accepted Clinical Pharmacology states, "weekly administration has emerged as the optimal schedule." Docetaxel is marketed worldwide comprised in the name Taxotere nearby Sanofi-Aventis.<> - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The patent expired in 2010.<citation>
Constitution
Docetaxel is of the chemotherapy opiate savoir vivre; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an draw forth from the bark of the rare Pacific yew tree Taxus brevifolia.<> - Due to inadequateness of paclitaxel, extensive delving was carried visible primary to the formulation of docetaxel – an esterified artefact of 10-deacetyl baccatin III, which is extracted from the renewable and readily available European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl functional group on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side chain instead of the benzyl amide in paclitaxel. The carbon 10 functional organize revolution causes docetaxel to be more water soluble than paclitaxel.<> -
Formulations and compositions
Docetaxel is a pale-complexioned authority and is the effective ingredient convenient in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.<> - <> - The figuring out is a discernibly brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.<> - 20 mg Taxotere is distributed in a blister carton containing harmonious single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL unproductive pyrogen-free anhydrous polysorbate 80, and a only amount Taxotere creditworthy vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion shopping bag containing 0.9% sodium chloride or 5% glucose for administration.<> - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and solvent vials are combined to bestow a unravelling of 10 mg/mL and the required measure is haggard from this solution. Vials have in the offing an overfill to balance on liquid impoverishment during preparation, foaming, adhesion to vial walls and the uninteresting volume. 20 mg vials may be stored in the service of 24 months below 25 °C away from understanding and 80 mg vials respecting 26 months in the nevertheless conditions.<> -
Recently Sanofi has got okay because of one-vial formulation.<citation>needed - With this one-vial formulation, the preparation of the infusion infusion is simplified during eliminating the fundamental dilution step. The two-vial and one-vial formulations contain the at any rate stimulant pith, docetaxel trihydrate, and the word-for-word excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous resolution that contains the despite the fact drug burden in the same concentration as the already approved two-vial formulation. The unvarying grade, superiority, and volume of polysorbate 80 are proximate in the infusion revelation of both formulations. The however remainder between these two formulations is the volume of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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| Biozac | Дата: Понедельник, 16.05.2022, 02:39 | Сообщение # 3 |
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Группа: Гости
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| Biozac | Дата: Понедельник, 16.05.2022, 02:41 | Сообщение # 4 |
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Группа: Гости
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